A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

被引：52

作者：

Torres, A

Hochberg, M

Pergament, I

Smoum, R

Niddam, V

Dembitsky, VM

Temina, M

Dor, I

Lev, O

Srebnik, M

Enk, CD

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Teva Pharmaceut Ind Ltd, Petah Tiqwa, Israel

[3] Hebrew Univ Jerusalem, Fredy & Nadine Herrmann Grad Sch Appl Sci, Div Environm Sci, IL-91905 Jerusalem, Israel

[4] Hadassah Univ Hosp, Dept Dermatol, IL-91120 Jerusalem, Israel

[5] Univ Haifa, Inst Ecol, IL-31999 Haifa, Israel

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2004年 / 271卷 / 04期

关键词：

lichenized ascomycete; Collema cristatum; mycosporine; photo protective activity; UV-B;

D O I：

10.1111/j.1432-1033.2004.03981.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

引用

页码：780 / 784

页数：5

共 26 条

[1]

Bandaranayake WM, 1998, NAT PROD REP, V15, P159

[2] Photoimmunology, DNA repair and photocarcinogenesis [J].