Cutting edge:: The common γ-chain is an indispensable subunit of the IL-21 receptor complex

被引：445

作者：

Asao, H

Okuyama, C

Kumaki, S

Ishii, N

Tsuchiya, S

Foster, D

Sugamura, K

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Inst Dev Aging & Canc, Dept Pediat Oncol, Sendai, Miyagi 980, Japan

[3] Zymogenet Inc, Dept Funct Cloning, Seattle, WA 98102 USA

[4] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 167卷 / 01期

关键词：

D O I：

10.4049/jimmunol.167.1.1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The common gamma -chain (gamma (c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma (c) is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on gamma (c)-deficient ED40515(-) cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in ED gamma -16 cells, a gamma (c)-transfected ED40515- cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)I, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the gamma (c). These data clearly demonstrate that the gamma (c) is an indispensable subunit of the functional IL-21R complex.

引用

收藏

页码：1 / 5

页数：5

相关论文

共 29 条

[1]

ANDERSON DM, 1995, J BIOL CHEM, V270, P29862

[2] PSEUDO-HIGH AFFINITY INTERLEUKIN-2 (IL-2) RECEPTOR LACKS THE 3RD COMPONENT THAT IS ESSENTIAL FOR FUNCTIONAL IL-2 BINDING AND SIGNALING [J].

ARIMA, N ;

KAMIO, M ;

IMADA, K ;

HORI, T ;

HATTORI, T ;

TSUDO, M ;

OKUMA, M ;

UCHIYAMA, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1265-1272

[3] INTERLEUKIN 2-INDUCED ACTIVATION OF JAK3 - POSSIBLE INVOLVEMENT IN SIGNAL-TRANSDUCTION FOR C-MYC INDUCTION AND CELL-PROLIFERATION [J].

ASAO, H ;

TANAKA, N ;

ISHII, N ;

HIGUCHI, M ;

TAKESHITA, T ;

NAKAMURA, M ;

SHIRASAWA, T ;

SUGAMURA, K .

FEBS LETTERS, 1994, 351 (02) :201-206

[4] Interferon-γ has dual potentials in inhibiting or promoting cell proliferation [J].

Asao, H ;

Fu, XY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :867-874

[5] RECONSTITUTION OF FUNCTIONAL INTERLEUKIN-2 RECEPTOR COMPLEXES ON FIBROBLASTOID CELLS - INVOLVEMENT OF THE CYTOPLASMIC DOMAIN OF THE GAMMA-CHAIN IN 2 DISTINCT SIGNALING PATHWAYS [J].

ASAO, H ;

TAKESHITA, T ;

ISHII, N ;

KUMAKI, S ;

NAKAMURA, M ;

SUGAMURA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4127-4131

[6] PREVENTION OF T-CELL ANERGY BY SIGNALING THROUGH THE GAMMA(C) CHAIN OF THE IL-2 RECEPTOR [J].

BOUSSIOTIS, VA ;

BARBER, DL ;

NAKARAI, T ;

FREEMAN, GJ ;

GRIBBEN, JG ;

BERNSTEIN, GM ;

DANDREA, AD ;

RITZ, J ;

NADLER, LM .

SCIENCE, 1994, 266 (5187) :1039-1042

[7] DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN [J].

CAO, XQ ;

SHORES, EW ;

HULI, J ;

ANVER, MR ;

KELSALL, BL ;

RUSSELL, SM ;

DRAGO, J ;

NOGUCHI, M ;

GRINBERG, A ;

BLOOM, ET ;

PAUL, WE ;

KATZ, SI ;

LOVE, PE ;

LEONARD, WJ .

IMMUNITY, 1995, 2 (03) :223-238

[8] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].

DARNELL, JE ;

KERR, IM ;

STARK, GR .

SCIENCE, 1994, 264 (5164) :1415-1421

[9] LYMPHOID DEVELOPMENT IN MICE WITH A TARGETED DELETION OF THE INTERLEUKIN-2 RECEPTOR-GAMMA CHAIN [J].

DISANTO, JP ;

MULLER, W ;

GUYGRAND, D ;

FISCHER, A ;

RAJEWSKY, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :377-381

[10] IDENTIFICATION AND CLONING OF A NOVEL IL-15 BINDING-PROTEIN THAT IS STRUCTURALLY RELATED TO THE ALPHA-CHAIN OF THE IL-2 RECEPTOR [J].

GIRI, JG ;

KUMAKI, S ;

AHDIEH, M ;

FRIEND, DJ ;

LOOMIS, A ;

SHANEBECK, K ;

DUBOSE, R ;

COSMAN, D ;

PARK, LS ;

ANDERSON, DM .

EMBO JOURNAL, 1995, 14 (15) :3654-3663