Synthesis of the racemic tetracyclic core of CP-225,917 - a model compound lacking the sidearms of the natural product

被引：18

作者：

Clive, DLJ ^{[1
]}

Sun, SY ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 36期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Peterson reaction; anhydride; lactone; ruthenium dioxide; bridgehead olefin; quaternary carbon;

D O I：

10.1016/S0040-4039(01)01286-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compound 3, representing the tetracyclic core structure of CP-225,917, was prepared from bridgehead olefin 9, which was first converted into ketone 13. Peterson olefination then gave 15, and this was elaborated into the anhydride 19, from which crystalline 3 was reached by a sequence of deprotection and oxidation steps. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：6267 / 6270

页数：4

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