Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

被引：249

作者：

Takakura, N

Huang, XL

Naruse, T

Hamaguchi, I

Dumont, DJ

Yancopoulos, GD

Suda, T

机构：

[1] Kumamoto Univ, Sch Med, Dept Cell Differentat, Inst Mol Embryol & Genet, Kumamoto 8600811, Japan

[2] Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Canc Biol, Toronto, ON M4N 3M5, Canada

[3] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

来源：

IMMUNITY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(00)80665-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated the function of TIE2/TEK receptor tyrosine kinase in the development of definitive hematopoiesis. In the vitelline artery at 9.5 days post-coitum (d.p.c.), TIE2(+) hematopoietic cells aggregated and adhered to TIE2(+) endothelial cells. Soluble TIE2-Fc chimeric protein inhibited the development of hematopoiesis and angiogenesis in the para-aortic splanchnopleural mesoderm (P-Sp) explant culture, and TIE2-deficient mice showed severely impaired definitive hematopoiesis. An in vitro study revealed that Angiopoietin-1 but not Angiopoietin-2 promoted the adhesion to fibronectin (FN) through integrins in TIE2-transfected cells and primary TIE2+ cells sorted from 9.5 d.p.c. P-Sp. Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells.

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页码：677 / 686

页数：10

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