Apoptosis: A new twist to the tale?

被引：13

作者：

Warbrick, E

机构：

[1] Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(02)70663-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA helicases XPB and XPD, components of transcription factor TFIIH, have been implicated in a p53-induced apoptotic pathway, These new findings suggest a role for the core TFIIH complex. in the coordination, not only of transcription, the cell cycle and DNA repair, but also of apoptosis.

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收藏

页码：1057 / 1059

页数：3

相关论文

共 10 条

[1] Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis [J].

Attardi, LD ;

Lowe, SW ;

Brugarolas, J ;

Jacks, T .

EMBO JOURNAL, 1996, 15 (14) :3693-3701

[2] P53-DEPENDENT APOPTOSIS IN THE ABSENCE OF TRANSCRIPTIONAL ACTIVATION OF P53-TARGET GENES [J].

CAELLES, C ;

HELMBERG, A ;

KARIN, M .

NATURE, 1994, 370 (6486) :220-223

[3] INDUCTION OF APOPTOSIS IN HELA-CELLS BY TRANS-ACTIVATION-DEFICIENT P53 [J].

HAUPT, Y ;

ROWAN, S ;

SHAULIAN, E ;

VOUSDEN, KH ;

OREN, M .

GENES & DEVELOPMENT, 1995, 9 (17) :2170-2183

[4] Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations [J].

Leveillard, T ;

Andera, L ;

Bissonnette, N ;

Schaeffer, L ;

Bracco, L ;

Egly, JM ;

Wasylyk, B .

EMBO JOURNAL, 1996, 15 (07) :1615-1624

[5]

MIDGLEY CA, 1995, J CELL SCI, V108, P1843

[6] ESSENTIAL ROLE FOR P53-MEDIATED TRANSCRIPTION IN E1A-INDUCED APOPTOSIS [J].

SABBATINI, P ;

LIN, JY ;

LEVINE, AJ ;

WHITE, E .

GENES & DEVELOPMENT, 1995, 9 (17) :2184-2192

[7] MYC-MEDIATED APOPTOSIS REQUIRES WILD-TYPE P53 IN A MANNER INDEPENDENT OF CELL-CYCLE ARREST AND THE ABILITY OF P53 TO INDUCE P21(WAF1/CIP1) [J].

WAGNER, AJ ;

KOKONTIS, JM ;

HAY, N .

GENES & DEVELOPMENT, 1994, 8 (23) :2817-2830

[8] P53 MODULATION OF TFIIH-ASSOCIATED NUCLEOTIDE EXCISION-REPAIR ACTIVITY [J].

WANG, XW ;

YEH, H ;

SCHAEFFER, L ;

ROY, R ;

MONCOLLIN, V ;

EGLY, JM ;

WANG, Z ;

FRIEDBERG, EC ;

EVANS, MK ;

TAFFE, BG ;

BOHR, VA ;

WEEDA, G ;

HOEIJMAKERS, JHJ ;

FORRESTER, K ;

HARRIS, CC .

NATURE GENETICS, 1995, 10 (02) :188-195

[9] The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway [J].

Wang, XW ;

Vermeulen, W ;

Coursen, JD ;

Gibson, M ;

Lupold, SE ;

Forrester, K ;

Xu, GW ;

Elmore, L ;

Yeh, H ;

Hoeijmakers, JHJ ;

Harris, CC .

GENES & DEVELOPMENT, 1996, 10 (10) :1219-1232

[10] BINDING OF BASAL TRANSCRIPTION FACTOR TFIIH TO THE ACIDIC ACTIVATION DOMAINS OF VP16 AND P53 [J].

XIAO, H ;

PEARSON, A ;

COULOMBE, B ;

TRUANT, R ;

ZHANG, S ;

REGIER, JL ;

TRIEZENBERG, SJ ;

REINBERG, D ;

FLORES, O ;

INGLES, CJ ;

GREENBLATT, J .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (10) :7013-7024