Regulation of adaptive immunity by the NLRP3 inflammasome

被引：71

作者：

Chen, Mingkuan ^{[1
]}

Wang, Hongbin ^{[1
]}

Chen, Wei ^{[1
]}

Meng, Guangxun ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Pasteur Shanghai, Unit Innate Immun, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 05期

关键词：

NLRP3; Inflammasome; Adaptive immunity; Adjuvant; CD4(+) T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PARTICULATE VACCINE ADJUVANTS; NALP3; INFLAMMASOME; CUTTING EDGE; DENDRITIC CELLS; PATHOGEN RECOGNITION; PATTERN-RECOGNITION; INTRACELLULAR DNA; INDUCED ARTHRITIS;

D O I：

10.1016/j.intimp.2010.11.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a prerequisite for the maturation of interleukin (IL)-1 beta and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity. (C) 2010 Elsevier B.V. All rights reserved.

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收藏

页码：549 / 554

页数：6

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