The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

被引：36

作者：

Tabner, BJ

Turnbull, S

Fullwood, NJ

German, M

Allsop, D ^{[1
]}

机构：

[1] Univ Lancaster, Dept Biol Sci, Lancaster LA1 4YQ, England

[2] Univ Lancaster, Magnet Resonance Lab, Lancaster LA1 4YQ, England

[3] Univ Lancaster, Dept Phys, Lancaster LA1 4YQ, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

基金：

英国惠康基金;

关键词：

Alzheimer's disease; H2O2; neuradegeneration; Parkinson's disease; prion; protein aggregation;

D O I：

10.1042/BST0330548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.

引用

页码：548 / 550

页数：3

共 12 条

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