Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

被引：67

作者：

Casarotto, Silvia ^{[1
]}

Maatta, Sara ^{[2
]}

Herukka, Sanna-Kaisa ^{[3
,5
]}

Pigorini, Andrea ^{[1
]}

Napolitani, Martino ^{[1
]}

Gosseries, Olivia ^{[8
]}

Niskanen, Eini ^{[2
,4
,6
]}

Kononen, Mervi ^{[2
,4
]}

Mervaala, Esa ^{[2
,7
]}

Rosanova, Mario ^{[1
]}

Soininen, Hilkka ^{[5
]}

Massimini, Marcello ^{[1
]}

机构：

[1] Univ Milan, Dept Clin Sci L Sacco, I-20157 Milan, Italy

[2] Kuopio Univ Hosp, Dept Clin Neurophysiol, Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland

[4] Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland

[5] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[6] Univ Eastern Finland, Dept Appl Phys, Kuopio, Finland

[7] Univ Eastern Finland, Dept Clin Neurophysiol, Kuopio, Finland

[8] Univ Liege, Cyclotron Res Ctr, Coma Sci Grp, Liege, Belgium

来源：

NEUROREPORT | 2011年 / 22卷 / 12期

关键词：

aging; Alzheimer; cortical excitability; electroencephalography; transcranial magnetic stimulation; MOTOR CORTEX EXCITABILITY; ALZHEIMERS-DISEASE; CORTICAL REACTIVITY; BRAIN; CONNECTIVITY; RESPONSES; TMS; CIRCUITS; EEG;

D O I：

10.1097/WNR.0b013e328349433a

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment. NeuroReport 22:592-597 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：592 / 597

页数：6

共 25 条

[1]

Transcranial magnetic stimulation in Alzheimer disease: motor cortex excitability and cognitive severity [J].