Sirtuin 1 in malignant transformation: Friend or foe?

被引：88

作者：

Fang, Yujiang ^{[1
]}

Nicholl, Michael B. ^{[1
]}

机构：

[1] Univ Missouri, Ellis Fischel Canc Ctr, Dept Surg, Sch Med, Columbia, MO 65212 USA

来源：

CANCER LETTERS | 2011年 / 306卷 / 01期

关键词：

SIRT1 and cancer; DNA-DAMAGE; CELL-SURVIVAL; DEACETYLASE SIRT1; ANDROGEN RECEPTOR; MOUSE MODELS; CANCER; MICE; P53; TUMORIGENESIS; RESISTANCE;

D O I：

10.1016/j.canlet.2011.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and tumor suppressor. In this review, we summarize the available data regarding the role of SIRT1 in tumorigenesis, with a focus on the potential mechanisms. The seemingly controversial role of SIRT1 in tumorigenesis suggests that SIRT1 might play a dual role in different tissue contexts depending on the temporal and special distribution of different SIRT1 upstream and downstream factors. Clearly, the role of SIRT1 in tumorigenesis is poorly understood and more research is necessary to elucidate its function in the malignant process. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：10 / 14

页数：5

共 56 条

[1] Opinion - Survivin, cancer networks and pathway-directed drug discovery [J].

Altieri, Dario C. .

NATURE REVIEWS CANCER, 2008, 8 (01) :61-70

[2] Insulin secretion: SIRT4 gets in on the act [J].

Argmann, Carmen ;

Auwerx, Johan .

CELL, 2006, 126 (05) :837-839

[3] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[4] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[5] Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors [J].

Bradbury, C ;

Khanim, F ;

Hayden, R ;

Bunce, CM ;

White, DA ;

Drayson, MT ;

Craddock, C ;

Turner, BM .

LEUKEMIA, 2005, 19 (10) :1751-1759

[6] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[7] The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting [J].

Cardiff, RD ;

Anver, MR ;

Gusterson, BA ;

Hennighausen, L ;

Jensen, RA ;

Merino, MJ ;

Rehm, S ;

Russo, J ;

Tavassoli, FA ;

Wakefield, LM ;

Ward, JM ;

Green, JE .

ONCOGENE, 2000, 19 (08) :968-988

[8] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[9] Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice [J].

Cheng, HL ;

Mostoslavsky, R ;

Saito, S ;

Manis, JP ;

Gu, YS ;

Patel, P ;

Bronson, R ;

Appella, E ;

Alt, FW ;

Chua, KF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10794-10799

[10] Regulation of SIRT1 in cellular functions: Role of polyphenols [J].

Chung, Sangwoon ;

Yao, Hongwei ;

Caito, Samuel ;

Hwang, Jae-Woong ;

Arunachalam, Gnanapragasam ;

Rahman, Irfan .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2010, 501 (01) :79-90

← 1 2 3 4 5 6 →