Beyond counting photons: Trials and trends in vertebrate visual transduction

被引：196

作者：

Burns, ME ^{[1
]}

Arshavsky, VY

机构：

[1] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA

[3] Duke Univ, Med Ctr, Dept Ophthalmol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

NEURON | 2005年 / 48卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2005.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

For over 30 years, photoreceptors have been an outstanding model system for elucidating basic principles in sensory transduction and G protein signaling. Recently, photoreceptors have become an equally attractive model for studying many facets of neuronal cell biology. The primary goal of this review is to illustrate this rapidly growing trend. We will highlight the areas of active research in photoreceptor biology that reveal how different specialized compartments of the cell cooperate in fulfilling its overall function: converting photon absorption into changes in neurotransmitter release. The same trend brings us closer to understanding how defects in photoreceptor signaling can lead to cell death and retinal degeneration.

引用

页码：387 / 401

页数：15

共 216 条

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