3D printing of pearl/CaSO4 composite scaffolds for bone regeneration

被引：52

作者：

Du, Xiaoyu ^{[1
]}

Yu, Bin ^{[2
]}

Pei, Peng ^{[1
]}

Ding, Huifeng ^{[2
]}

Yu, Baoqing ^{[2
]}

Zhu, Yufang ^{[1
]}

机构：

[1] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China

[2] Fudan Univ, Shanghai Pudong Hosp, Dept Orthoped, Pudong Med Ctr, Shanghai 201399, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 03期

关键词：

BIOACTIVE GLASS SCAFFOLDS; IN-VITRO; CALCIUM-SULFATE; OSTEOGENIC ACTIVITY; GRAFT SUBSTITUTE; CEMENT SCAFFOLDS; PEARL POWDER; TISSUE; SILICATE; VIVO;

D O I：

10.1039/c7tb02667f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

The development of biomaterials with high osteogenic ability for fast osteointegration with a host bone is of great interest. In this study, pearl/CaSO4 composite scaffolds were fabricated using three-dimensional (3D) printing, followed by a hydration process. The pearl/CaSO4 scaffolds showed uniform interconnected macropores (similar to 400 mm), high porosity (B60%), and enhanced compressive strength. With CaSO4 scaffolds as a control, the biological properties of the pearl/CaSO4 scaffolds were evaluated in vitro and in vivo. The results showed that the pearl/CaSO4 scaffolds possessed a good apatite-forming ability and stimulated the proliferation and differentiation of rat bone mesenchymal stem cells (rBMSCs), as well as giving a better expression of related osteogenic genes. Importantly, micro-computed tomography and histology of the critical-sized rabbit femoral condyle defects implanted with the scaffolds illustrated the osteogenic capacity of the pearl/CaSO4 scaffolds. New bone was observed within 8 weeks. The bone-implant contact index was significantly higher for the pearl/CaSO4 scaffolds implant than for the CaSO4 scaffolds implant, indicating that the pearl/CaSO4 scaffolds would be promising implants for bone regeneration.

引用

页码：499 / 509

页数：11

共 43 条

[1]

Development of nanocomposite scaffolds based on TiO2 doped in grafted chitosan/hydroxyapatite by freeze drying method and evaluation of biocompatibility [J].