Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin

被引：29

作者：

Wiid, I

Hoal-van Helden, E

Hon, D

Lombard, C

van Helden, P

机构：

[1] Univ Stellenbosch, Sch Med, Dept Biochem Med,Fac Med, MRC,Ctr Mol & Cellular Biol, ZA-7505 Tygerberg, South Africa

[2] S African MRC, Ctr Epidemiol Res S Africa, ZA-7505 Tygerberg, South Africa

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.43.4.975

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.

引用

页码：975 / 977

页数：3

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