Glycoconjugates in New World species of Leishmania: Polymorphisms in lipophosphoglycan and glycoinositolphospholipids and interaction with hosts

被引:76
作者
de Assis, Rafael Ramiro [2 ]
Ibraim, Izabela Coimbra [2 ]
Nogueira, Paula Monalisa [2 ]
Soares, Rodrigo Pedro [2 ]
Turco, Salvatore J. [1 ]
机构
[1] Univ Kentucky, Med Ctr, Dept Biochem, Lexington, KY 40536 USA
[2] Fiocruz MS, Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2012年 / 1820卷 / 09期
关键词
Leishmania; New World; Lipophosphoglycan; Glycoinositolphospholipids; Host-parasite interaction; PROTEIN-KINASE-C; NITRIC-OXIDE SYNTHASE; SECRETED ACID-PHOSPHATASE; SAND FLY VECTOR; DONOVANI PROMASTIGOTES EVADE; SIGNAL-RELATED KINASE; VIANNIA BRAZILIENSIS; LUTZOMYIA-LONGIPALPIS; MICE LACKING; GLYCOSYLATED PHOSPHATIDYLINOSITOLS;
D O I
10.1016/j.bbagen.2011.11.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Background: Protozoan parasites of the genus Leishmania cause a number of important diseases in humans and undergo a complex life cycle, alternating between a sand fly vector and vertebrate hosts. The parasites have a remarkable capacity to avoid destruction in which surface molecules are determinant for survival. Amongst the many surface molecules of Leishmania, the glycoconjugates are known to play a central role in host-parasite interactions and are the focus of this review. Scope of the review: The most abundant and best studied glycoconjugates are the Lipophosphoglycans (LPGs) and glycoinositolphospholipids (GIPLs). This review summarizes the main studies on structure and biological functions of these molecules in New World Leishmania species. Major conclusions: LPG and GIPLs are complex molecules that display inter- and intraspecies polymorphisms. They are key elements for survival inside the vector and to modulate the vertebrate immune response during infection. General significance: Most of the studies on glycoconjugates focused on Old World Leishmania species. Here, it is reported some of the studies involving New World species and their biological significance on host-parasite interaction. This article is part of a Special Issue entitled Glycoproteomics. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1354 / 1365
页数:12
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