HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone

被引：30

作者：

Hemmelmann, Mirjam ^{[2
]}

Knoth, Christiane ^{[1
]}

Schmitt, Ulrich ^{[1
]}

Allmeroth, Mareli ^{[2
]}

Moderegger, Dorothea ^{[3
]}

Barz, Matthias ^{[2
]}

Koynov, Kaloian ^{[4
]}

Hiemke, Christoph ^{[1
]}

Roesch, Frank ^{[3
]}

Zentel, Rudolf ^{[2
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychiat & Psychotherapy, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55099 Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Inst Nucl Chem, D-55128 Mainz, Germany

[4] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2011年 / 32卷 / 9-10期

关键词：

blood-brain barrier; CNS activity; controlled radical polymerization; drug delivery systems; polymer micelles; P-GLYCOPROTEIN INHIBITOR; DIBLOCK COPOLYMERS; LOCOMOTOR-ACTIVITY; IN-VIVO; BRAIN; NANOPARTICLES; DELIVERY; DRUGS; POLYMERIZATION; MECHANISMS;

D O I：

10.1002/marc.201000810

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)-co-p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood-brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for CNS actions. Carefully designed copolymers based on the clinically approved p(HPMA) were selected and synthesized by a combination of controlled radical polymerization and post-polymerization modification. The hydrodynamic radii (Rh) of amphiphilic p(HPMA)-co-p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy.

引用

页码：712 / 717

页数：6

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