Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

被引：6

作者：

Dvorakova, D

Krejci, P

Mayer, J

Fajkus, J

Hampl, A

Dvorak, P

机构：

[1] Mendel Univ Brno, Mol Embryol Lab, Brno, Czech Republic

[2] Masaryk Univ Hosp, Dept Internal Med Haematooncol, Brno, Czech Republic

[3] Acad Sci Czech Republ, Inst Biophys, CS-61265 Brno, Czech Republic

[4] Acad Sci Czech Republ, Inst Anim Physiol & Genet, Dev Biol Unit, Brno, Czech Republic

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 03期

关键词：

fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis;

D O I：

10.1046/j.1365-2141.2001.02829.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor receptors (FGFR1-4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that. in CML, the changing levels of FGFR3 transcripts in WBCs map have prognostic significance.

引用

页码：832 / 835

页数：4

共 11 条

[1] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [J].