Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin

被引：38

作者：

Duncan, RE

El-Sohemy, A

Archer, MC

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada

[2] Univ Toronto, Fac Med, Dept Med Biophys, Toronto, ON M5S 3E2, Canada

来源：

CANCER LETTERS | 2005年 / 224卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

HMG-CoA reductase; breast cancer; genistein; docosahexaenoic acid; eicosapentaenoic acids; mevastatin;

D O I：

10.1016/j.canlet.2004.11.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We investigated the regulation of HMG-CoA reductase in MCF-7 human breast cancer cells by genistein, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DRA). All three compounds down-regulated reductase activity, primarily through post-transcriptional effects. In mevastatin-treated cells, only genistein and DHA abrogated the induction of reductase activity caused by this competitive inhibitor. Diets rich in soy isoflavones and fish oils, therefore, may exert anti-cancer effects through the inhibition of mevalonate synthesis in the breast. Genistein and DHA, in particular, may augment the efficacy of statins, increasing the potential for use of these drugs in adjuvant therapy for breast cancer. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：221 / 228

页数：8

共 46 条

[1]

Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis [J].