Glycosides from the root of Iodes cirrhosa

被引：164

作者：

Gan, Maoluo

Zhang, Yanling

Lin, Sheng

Liu, Mingtao

Song, Weixia

Zi, Jiachen

Yang, Yongchun

Fan, Xiaona

Shi, Jiangong ^{[1
]}

Hu, Jinfeng

Sun, Jiandong

Chen, Naihong

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 04期

关键词：

D O I：

10.1021/np7007329

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new neolignan glycosides (1-7), two arylglycerol glycosides (8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of lodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8-4'-oxyneolignans and arylglycerols in different solvents, the validity of J(7,8) and Delta delta(C8-C7) values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin (17) both showed activity against glutamate-induced PC12 cell damage at 10(-5) M.

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收藏

页码：647 / 654

页数：8

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