Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease

被引：12

作者：

Conraads, VM

Bosmans, JM

Schuerwegh, AJ

De Clerck, LS

Bridts, CH

Wuyts, FL

Stevens, WJ

Vrints, CJ

机构：

[1] Univ Antwerp Hosp, Dept Cardiol, B-2650 Edegem, Belgium

[2] Univ Antwerp Hosp, Dept Immunol, B-2650 Edegem, Belgium

[3] Univ Antwerp Hosp, Dept Med Stat, B-2650 Edegem, Belgium

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2005年 / 24卷 / 08期

关键词：

D O I：

10.1016/j.healun.2004.08.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antiinflammatory effect of lipoproteins through neutralization of circulating endotoxin has questioned the safety of lipid-lowering drugs in chronic heart failure (CHF). We measured serum levels of interleukin-6, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors 1 and 2 before and after 1-month treatment with pravastatin 40 mg in 58 patients with CHF. Short-term treatment with pravastatin attenuated the immune response in patients with CHF due to ischemic or nonischemic etiology.

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收藏

页码：1114 / 1117

页数：4

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