Tissue microarrays: bridging the gap between research and the clinic

被引：50

作者：

Braunschweig, T

Chung, JY

Hewitt, SM ^{[1
]}

机构：

[1] NCI, Tissue Array Res Program, Pathol Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] Inje Univ, Coll Med, PharmacoGenom Res Ctr, Pusan, South Korea

[3] Inje Univ, Coll Med, Mol Cell Physiol Res Grp, Pusan 614735, South Korea

来源：

EXPERT REVIEW OF PROTEOMICS | 2005年 / 2卷 / 03期

关键词：

cell line; clinical trials; high throughput; histology methodologies; pathology; proteomics; tissue microarray; TMA; translational medicine; xenograft;

D O I：

10.1586/14789450.2.3.325

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue microarrays are a high-throughput method for the Investigation of biomarkers in multiple tissue specimens at once. This technique allows for the analysis of up to 500 tissue samples in a single experiment using immunohistochemistry and in situ hybridization. Recently, cell lines and xenografts have been reduced to a tissue microarray format and are being applied to preclinical drug development. In clinical research, tissue microarrays are applied at multiple levels: comprehensive analysis of samples in the context of a clinical trial or across a population. Tissue microarrays play a central role in translational research, facilitating the discovery of molecules that have potential roles in the diagnosis, prognosis and prediction of response to therapy.

引用

页码：325 / 336

页数：12

共 81 条

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