Is there a place for different isoforms of FSH in clinical medicine? IV. The clinician's point of view

被引：8

作者：

Baird, DT ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Reprod Biol, Edinburgh EH3 9ET, Midlothian, Scotland

来源：

HUMAN REPRODUCTION | 2001年 / 16卷 / 07期

关键词：

anovulatory infertility in women; clinical medicine; FSH isoforms; hypogonadotrophic men;

D O I：

10.1093/humrep/16.7.1316

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Follicle stimulating hormone (FSH) plays an important role in gametogenesis in both men and women. In men it is required for the establishment and probably maintenance of spermatogenesis. In women it stimulates the growth of ovarian follicles and fluctuations in its secretion are involved in the selection of the ovulatory follicle. It is now possible by recombinant DNA technology to synthesize a range of isoforms of FSH with differing biological action and half-life which would provide a greater degree of flexibility in the treatment of women with anovulatory infertility. Longer acting isoforms of FSH would find clinical application in the treatment of hypogonadotrophic men.

引用

页码：1316 / 1318

页数：3

共 25 条

[1]

Baird DT, 1997, ANDROGEN EXCESS DISORDERS IN WOMEN, P749

[2]

BAIRD DT, 1994, INT CONGR SER, V1046, P135

[3]

Baird DT, 1993, OVARY, P529

[4]

Baire R., 1899, ANN MAT PUR APPL, V3, P1, DOI DOI 10.1007/BF02419243