Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

被引：59

作者：

Sklar, P ^{[1
]}

Schwab, SG

Williams, NM

Daly, M

Schaffner, S

Maier, W

Albus, M

Trixler, M

Eichhammer, P

Lerer, B

Hallmayer, J

Norton, N

Williams, H

Zammit, S

Cardno, AG

Jones, S

McCarthy, G

Milanova, V

Kirov, G

O'Donovan, MC

Lander, ES

Owen, MJ

Wildenauer, DB

机构：

[1] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

[4] Univ Bonn, Dept Psychiat, Genet Mol Lab, D-53111 Bonn, Germany

[5] Cardiff Univ, Dept Psychol Med, Cardiff CF4 4XN, S Glam, Wales

[6] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

[7] Mental State Hosp, D-85529 Haar, Germany

[8] Univ Pecs, Sch Med, Dept Psychiat, H-7623 Pecs, Hungary

[9] Univ Regensburg, Dept Psychiat, D-93042 Regensburg, Germany

[10] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Psychiat, IL-91120 Jerusalem, Israel

[11] Univ Western Australia, Graylands Hosp, Ctr Clin Res Neuropscyhiat, Mtr Claremont, WA 6010, Australia

[12] Med Univ Sofia, Dept Psychiat, Sofia 1431, Bulgaria

来源：

NATURE GENETICS | 2001年 / 28卷 / 02期

基金：

美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/88836

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genetic association between NOTCH4 and schizophrenia has previously been proposed(1). Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton, These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

引用

页码：126 / 128

页数：3

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