Behavioral and neurochemical effects of sodium butyrate in an animal model of mania

被引：85

作者：

Moretti, Morgana ^{[1
,2
]}

Valvassori, Samira S. ^{[1
,2
]}

Varela, Roger B. ^{[1
,2
]}

Ferreira, Camila L. ^{[1
,2
]}

Rochi, Natalia ^{[2
,3
]}

Benedet, Joana ^{[2
,3
]}

Scaini, Giselli ^{[2
,3
]}

Kapczinski, Flavio ^{[5
,6
]}

Streck, Emilio L. ^{[2
,3
]}

Zugno, Alexandra I. ^{[2
,3
]}

Quevedo, Joao ^{[1
,2
,4
]}

机构：

[1] Univ So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Neurosci Lab, Criciuma, SC, Brazil

[2] Univ So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Natl Inst Translat Med, Criciuma, SC, Brazil

[3] Univ So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Lab Expt Pathophysiol, Criciuma, SC, Brazil

[4] Sao Jose Hosp, Res Ctr, Lab Translat Psychiat, Criciuma, SC, Brazil

[5] Univ Fed Rio Grande do Sul, Bipolar Disorders Program, Lab Mol Psychiat, Porto Alegre, RS, Brazil

[6] Univ Fed Rio Grande do Sul, Natl Inst Translat Med, Porto Alegre, RS, Brazil

来源：

BEHAVIOURAL PHARMACOLOGY | 2011年 / 22卷 / 08期

关键词：

creatine kinase; locomotor activity; mania; mitochondrial respiratory chain; sodium butyrate; HISTONE DEACETYLASE INHIBITORS; BIPOLAR DISORDER; VALPROIC ACID; AMPHETAMINE EXPOSURE; OXIDATIVE STRESS; MOOD-STABILIZER; BRAIN; CHAIN; PATHOPHYSIOLOGY; HIPPOCAMPUS;

D O I：

10.1097/FBP.0b013e32834d0f1b

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

The present study investigated the effect of the histone deacetylase inhibitor, sodium butyrate (SB), on locomotor behavior and on mitochondrial respiratory-chain complexes activity in the brain of rats subjected to an animal model of mania induced by d-amphetamine (d-AMPH). In the reversal treatment, Wistar rats were first treated with d-AMPH or saline (Sal) for 14 days. Thereafter, between days 8 and 14, rats were administered SB or Sal. In the prevention treatment, rats were treated with SB or Sal for 14 days and received d-AMPH or Sal between days 8 and 14. The d-AMPH treatment increased locomotor behavior in Sal-treated rats under reversion and prevention treatment, and SB reversed and prevented d-AMPH-related hyperactivity. Moreover, d-AMPH decreased the activity of mitochondrial respiratory-chain complexes in Sal-treated rats in the prefrontal cortex, hippocampus, striatum, and amygdala in both experiments, and SB was able to reverse and prevent this impairment. The present study suggests that the mechanism of action of SB involves induction of mitochondrial function in parallel with behavioral changes, reinforcing the need for more studies on histone deacetylase inhibitors as a possible target for new medications for bipolar disorder treatment. Behavioural Pharmacology 22:766-772 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：766 / 772

页数：7

共 45 条

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders [J].