The scent of disease: volatile organic compounds of the human body related to disease and disorder

被引：432

作者：

Shirasu, Mika ^{[1
]}

Touhara, Kazushige ^{[1
]}

机构：

[1] Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2011年 / 150卷 / 03期

关键词：

biomarker; disease; disorder; metabolism; odour; olfactory; volatile organic compound; METHIONINE ADENOSYLTRANSFERASE DEFICIENCY; FLAVIN-CONTAINING MONOOXYGENASE-3; CHROMATOGRAPHY-MASS SPECTROMETRY; LUNG-CANCER; ISOVALERIC ACIDEMIA; ELECTRONIC-NOSE; CHARACTERISTIC ODOR; IN-VITRO; MYCOBACTERIUM-TUBERCULOSIS; SCHIZOPHRENIC-PATIENTS;

D O I：

10.1093/jb/mvr090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hundreds of volatile organic compounds (VOCs) are emitted from the human body, and the components of VOCs usually reflect the metabolic condition of an individual. Therefore, contracting an infectious or metabolic disease often results in a change in body odour. Recent progresses in analytical techniques allow rapid analyses of VOCs derived from breath, blood, skin and urine. Disease-specific VOCs can be used as diagnostic olfactory biomarkers of infectious diseases, metabolic diseases, genetic disorders and other kinds of diseases. Elucidation of pathophysiological mechanisms underlying production of disease-specific VOCs may provide novel insights into therapeutic approaches for treatments for various diseases. This review summarizes the current knowledge on chemical and clinical aspects of body-derived VOCs, and provides a brief outlook at the future of olfactory diagnosis.

引用

页码：257 / 266

页数：10

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