The Dynamic Structure of Filamentous Tau

被引：68

作者：

Bibow, Stefan ^{[1
]}

Mukrasch, Marco D. ^{[1
]}

Chinnathambi, Subashchandrabose ^{[2
,3
,4
]}

Biernat, Jacek ^{[2
,3
,4
]}

Griesinger, Christian ^{[1
]}

Mandelkow, Eckhard ^{[2
,3
,4
]}

Zweckstetter, Markus ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany

[2] DESY, Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

[3] German Ctr Neurodegenerat Dis, DZNE, D-53175 Bonn, Germany

[4] CAESAR, D-53175 Bonn, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期

关键词：

aggregation; Alzheimer disease; fuzzy coat; paired helical filament; tau protein; PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; IN-VITRO; CORE; BETA; NEURODEGENERATION; FRAGMENTS; EPITOPES; STATE; NMR;

D O I：

10.1002/anie.201105493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting inside a fuzzy coat: The dynamic structure of the "fuzzy coat", N- and C-terminal sections around the core of the tau filament consists of over 200amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11520 / 11524

页数：5

共 28 条

[1] Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy [J].

Andronesi, Ovidiu C. ;

von Bergen, Martin ;

Biernat, Jacek ;

Seidel, Karsten ;

Griesinger, Christian ;

Mandelkow, Eckhard ;

Baldus, Marc .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) :5922-5928

[2] Tau-mediated neurodegeneration in Alzheimer's disease and related disorders [J].

Ballatore, Carlo ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) :663-672

[3] Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure [J].

Berriman, J ;

Serpell, LC ;

Oberg, KA ;

Fink, AL ;

Goedert, M ;

Crowther, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) :9034-9038

[4] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[5] The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology [J].

Carmel, G ;

Mager, EM ;

Binder, LI ;

Kuret, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :32789-32795

[6] Caspase activation precedes and leads to tangles [J].

de Calignon, Alix ;

Fox, Leora M. ;

Pitstick, Rose ;

Carlson, George A. ;

Bacskai, Brian J. ;

Spires-Jones, Tara L. ;

Hyman, Bradley T. .

NATURE, 2010, 464 (7292) :1201-U123

[7] MAGIC-ANGLE SAMPLE SPINNING OF LIQUIDS [J].

GARROWAY, AN .

JOURNAL OF MAGNETIC RESONANCE, 1982, 49 (01) :168-171

[8] Tau-66:: evidence for a novel tau conformation in Alzheimer's disease [J].

Ghoshal, N ;

García-Sierra, F ;

Fu, YF ;

Beckett, LA ;

Mufson, EJ ;

Kuret, J ;

Berry, RW ;

Binder, LI .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (05) :1372-1385

[9] Characterization of long-range structure in the denatured state of staphylococcal nuclease .2. Distance restraints from paramagnetic relaxation and calculation of an ensemble of structures [J].

Gillespie, JR ;

Shortle, D .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 268 (01) :170-184

[10] Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide [J].

Haass, Christian ;

Selkoe, Dennis J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (02) :101-112

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