Multiple and surprising new functions for emerin, a nuclear membrane protein

被引：104

作者：

Bengtsson, L ^{[1
]}

Wilson, KL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2003.11.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emeriti in the nucleus, some of which overlap with related LEM-domain proteins.

引用

页码：73 / 79

页数：7

共 54 条

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