An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment

被引:27
作者
Miller, Christopher B. [1 ,2 ]
Rae, Caroline D. [3 ,4 ]
Green, Michael A. [3 ]
Yee, Brendon J. [1 ,2 ,5 ]
Gordon, Christopher J. [1 ,6 ]
D'Rozario, Angela L. [1 ,7 ,8 ]
Kyle, Simon D. [9 ]
Espie, Colin A. [9 ]
Grunstein, Ronald R. [1 ,2 ,5 ]
Bartlett, Delwyn J. [1 ,2 ]
机构
[1] Ctr Sleep & Chronobiol, CIRUS, Woolcock Inst Med Res, Sydney, NSW, Australia
[2] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia
[3] Neurosci Res Australia, Randwick, NSW, Australia
[4] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
[5] Royal Prince Alfred Hosp, Dept Resp & Sleep Med, Sydney Local Hlth Dist, Sydney, NSW, Australia
[6] Univ Sydney, Sydney Nursing Sch, Sydney, NSW, Australia
[7] Univ Sydney, Fac Sci, Sch Psychol, Brain & Mind Ctr, Sydney, NSW, Australia
[8] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia
[9] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
基金
英国医学研究理事会;
关键词
sleep and the brain; insomnia; magnetic resonance spectroscopy; brain imaging and phenotyping; GAMMA-AMINOBUTYRIC-ACID; CORTICAL GABA LEVELS; ENHANCES SLOW-WAVE; ANTERIOR CINGULATE; GLUTAMATE; CREATINE; PRECURSORS; STABILITY; PHENOTYPE; DURATION;
D O I
10.1093/sleep/zsx148
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Objectives: To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs). Methods: PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). H-1 magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water). Glutathione, glycerophosphocholine, lactate, myoinositol, and N-acetylaspartate measurements were also obtained. Sixteen GSCs were included for comparison. Multivariate analysis of variance was used to evaluate differences in creatine, aspartate, glutamate, and glutamine. Results: Aspartate and glutamine concentrations were reduced in the LOCC in I-SSD compared with I-NSD (both p<.05, d=.80-.99). Creatine displayed a nonsignificant mean reduction in I-SSD compared with I-NSD (p=.05, d=.58). Glutamine was reduced in I-SSD compared with controls (p<.05, d=.93). There were no differences in metabolites between all (I-SSD and I-NSD) insomnia patients and controls. In patients with insomnia, LOCC glutamine concentrations were found to be positively correlated with TST (r=.43, p<.05) and negatively correlated with wake-time after sleep onset (r =-.40, p<.05). Conclusions: Results indicate that I-SSD is associated with reduced brain metabolites in the LOCC compared with I-NSD and control concentrations of aspartate, glutamine, and creatine.
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页数:11
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