Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic carbenes

被引：854

作者：

Nair, V ^{[1
]}

Rajesh, C ^{[1
]}

Vinod, AU ^{[1
]}

Bindu, S ^{[1
]}

Sreekanth, AR ^{[1
]}

Mathen, JS ^{[1
]}

Balagopal, L ^{[1
]}

机构：

[1] CSIR, Organ Chem Div, Trivandrum 695019, Kerala, India

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2003年 / 36卷 / 12期

关键词：

D O I：

10.1021/ar020258p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.

引用

页码：899 / 907

页数：9

共 59 条

[1] REACTIONS OF ACETYLENECARBOXYLIC ACIDS AND THEIR ESTERS WITH NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS [J].