Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism

被引：221

作者：

ALjohani, Ahmed M. ^{[1
,2
]}

Syed, Deeba N. ^{[3
]}

Ntambi, James M. ^{[4
,5
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Endocrinol & Reprod Physiol Grad Training Program, Madison, WI 53706 USA

[2] King Saud bin Abdulaziz Univ Hlth Sci, Natl Guard Hlth Affairs, Riyadh 11426, Saudi Arabia

[3] Univ Wisconsin, Dept Dermatol, Sch Med & Publ Hlth, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[5] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 12期

关键词：

POLYUNSATURATED FATTY-ACIDS; ELEMENT-BINDING PROTEIN; ADIPOSE-TISSUE; SKELETAL-MUSCLE; GENE-EXPRESSION; MEDIATED ACTIVATION; GLUCOSE-UTILIZATION; DIETARY-REGULATION; INSULIN; DEFICIENCY;

D O I：

10.1016/j.tem.2017.10.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.

引用

页码：831 / 842

页数：12

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