5% Imiquimod cream for external anogenital warts in HIV-infected patients under HAART therapy

被引：35

作者：

Cusini, M ^{[1
]}

Salmaso, F ^{[1
]}

Zerboni, R ^{[1
]}

Carminati, G ^{[1
]}

Vernaci, C ^{[1
]}

Franchi, C ^{[1
]}

Locatelli, A ^{[1
]}

Alessi, E ^{[1
]}

机构：

[1] Osped Maggiore, IRCCS, Ist Sci Dermatol, Ctr Malattie Trasmiss Sessuale, I-20122 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2004年 / 15卷 / 01期

关键词：

imiquimod; external genital warts; HIV-infection;

D O I：

10.1258/095646204322637191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The efficacy of imiquimod in the treatment of external genital warts in HIV positive subjects was compared to a group of patients with normal immune function. Imiquimod 5% cream was applied by patients three times a week until resolution for a maximum of 16 weeks. Assessment for response and the occurrence of side effects was performed every four weeks. Thirty-one per cent of 75 HIV positive patients achieved a complete clearance, a partial response was obtained in 24% of subjects while in 45% we observed no clinical response. In the control group a total clearance was obtained in 62% of subjects, a partial response in 24% and no response in 14%. Recurrences occurred in 4/23 HIV patients and 2/31 immunocompetent patients within three months of follow-up. Side effects were minor to moderate. We conclude that imiquimod 5% cream has an acceptable efficacy and safety on HIV patients.

引用

页码：17 / 20

页数：4

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