KIR matching in hematopoietic stem cell transplantation

被引：44

作者：

Bignon, JD ^{[1
]}

Gagne, K ^{[1
]}

机构：

[1] Etab Francais Sang, HLA Lab, F-44011 Nantes, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.coi.2005.07.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Although the key role of MHC-restricted T lymphocytes in hematopoietic stem cell transplantation (HSCT) has been known for a long time, recent data have focused on complementary or alternative effector cell populations, and in particular on NK cells. Spontaneously generated NK cell alloreactivity from stem cell grafts involves specific interactions between NK receptors, including killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands. The combined effects of HLA and KIR polymorphic genes might explain discrepancies in the impact of donor-recipient matching observed in HSCT.

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收藏

页码：553 / 559

页数：7

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