True density of microcrystal line cellulose

被引：193

作者：

Sun, CQ ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Portage, MI 49001 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2005年 / 94卷 / 10期

关键词：

excipients; crystallinity; mechanical properties; tableting; powder technology;

D O I：

10.1002/jps.20459

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Microcrystalline cellulose (MCC) exhibits unusual tableting properties, sometimes, inconsistent with its high plasticity. It is found that some of the unusual tableting properties of MCC can be explained in part by the use of inaccurate true density during tableting data analysis. MCC true density as a function of water content is determined using a published method that can determine true density of water containing solids. Results suggest that literature MCC true densities tend to be overestimated as a result of limitations in helium pycnometry. (c) 2005 Wiley-Liss, Inc.

引用

页码：2132 / 2134

页数：3

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