Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia

被引：39

作者：

Chagan-Yasutan, Haorile ^{[1
]}

Tsukasaki, Kunihiro ^{[2
]}

Takahashi, Yayoi ^{[3
]}

Oguma, Shigeru ^{[4
]}

Harigae, Hideo ^{[5
]}

Ishii, Naoto ^{[6
]}

Zhang, Jing ^{[7
]}

Fukumoto, Manabu ^{[8
]}

Hattori, Toshio ^{[1
]}

机构：

[1] Tohoku Univ, Div Emerging Infect Dis, Dept Internal Med, Grad Sch Med,Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Med & Hematol, Mol Med Unit,Atom Bomb Dis Inst, Nagasaki 852, Japan

[3] Tohoku Univ Hosp, Dept Pathol, Sendai, Miyagi, Japan

[4] Takeda Gen Hosp, Med Informat Div, Kyoto, Japan

[5] Tohoku Univ Hosp, Div Hematol & Rheumatol, Sendai, Miyagi, Japan

[6] Tohoku Univ, Div Microbiol & Immunol, Grad Sch Med, Sendai, Miyagi 9808574, Japan

[7] FUSO Pharmaceut Ind Ltd, Ctr Res & Dev, Osaka, Japan

[8] Tohoku Univ, Div Canc Control Pathol, Inst Dev Aging & Canc, Sendai, Miyagi 9808574, Japan

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 11期

关键词：

ATL; OPN; CD44; CD44v6; Prognostic factors; Immunohistochemical staining; TUMOR-ASSOCIATED MACROPHAGES; ADHESION MOLECULES; GENE-EXPRESSION; LYMPHOMA; RECEPTOR; CANCER; PROLIFERATION; GLYCOPROTEINS; LYMPHOCYTES; ACTIVATION;

D O I：

10.1016/j.leukres.2011.05.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We previously reported that the osteopontin (OPN) gene as well as CD44 is trans-activated by the Tax protein of HTLV-1, however the synthesis of both in adult T cell leukemia (ATL) has not been described yet. Here we showed the expression of these molecules in plasma and tissue of ATL. Significant differences were found among the normal and four subtypes of 27 ATL patients in plasma levels of OPN (p = 3.6 x 10(-6)) and soluble CD44 (p < 0.001) and they were significantly related to each other (p < 0.002). Also they were significantly associated with the performance status, total number of involved lesions, and lactic dehydrogenase, and inversely with lymphocyte count (p < 0.01). Immunohistochemical staining of lymph-nodes and skin from 7 ATL patients using anti-OPN and anti-CD44 antibodies demonstrated that both expressions were weak/moderate in ATL cells but moderate/strong in infiltrated macrophages in 6 patients. These results demonstrate that OPN and CD44 play important roles in tumor formations and their products in plasma could be markers of the severity in ATL. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1484 / 1490

页数：7

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