Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia

被引：123

作者：

Ilyushina, NA

Govorkova, EA

Webster, RG

机构：

[1] St Jude Childrens Res Hosp, Div Virol, Dept Infect Dis, Memphis, TN 38105 USA

[2] DI Ivanovskii Inst Virol, Moscow 123098, Russia

[3] Univ Tennessee, Dept Pathol, Memphis, TN 38163 USA

来源：

VIROLOGY | 2005年 / 341卷 / 01期

关键词：

avian influenza A virus; amantadine resistance; M2; protein;

D O I：

10.1016/j.virol.2005.07.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes). Drug-resistant variants were not detected among 1979 - 83 isolates, whereas 31.1% of H5 and 10.6% of H9 strains from Southeast Asia isolated in 2000-04 carried mutations in M2 protein. In North America, resistant variants occurred among H7 viruses only (16.4% of those tested). H6 viruses were amantadine-sensitive. These findings prompt concern regarding the control of pandemic influenza, the possibility that the next pandemic virus will be amantadine-resistant and the need to monitor the use of the drug in poultry. (c) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：102 / 106

页数：5

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