Regulation of an early developmental checkpoint in the B cell pathway by Ig beta

被引：237

作者：

Gong, SC ^{[1
]}

Nussenzweig, MC ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021

来源：

SCIENCE | 1996年 / 272卷 / 5260期

关键词：

D O I：

10.1126/science.272.5260.411

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig) M heavy chain (m mu) and the Ig alpha-Ig beta signal transducers. The role of Ig beta in regulating early B cell development was examined in mice that lack Ig beta (Ig beta(-/-)). These mice had a complete block in B cell development at the immature CD43(+)B220(+) stage. Immunoglobulin heavy chain diversity (D-H) and joining (J(H)) segments rearranged, but variable (V-H) to DJ(H) recombination and Immunoglobulin messenger RNA expression were compromised. These experiments define an unexpected, early requirement for Ig beta to produce B cells that can complete VDJ(H) recombination.

引用

页码：411 / 414

页数：4

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