Presentation and recognition of biotin on nanofibers formed by branched peptide amphiphiles

被引：108

作者：

Guler, MO ^{[1
]}

Soukasene, S ^{[1
]}

Hulvat, JF ^{[1
]}

Stupp, SI ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Chem, Dept Mat Sci & Engn, Evanston, IL 60208 USA

来源：

NANO LETTERS | 2005年 / 5卷 / 02期

关键词：

D O I：

10.1021/nl048238z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A branched peptide amphiphile system was designed for enhanced recognition of biotin on nanofibers formed by self-assembly of these molecules. Branching at a lysine residue was used to design peptide amphiphiles that are capable of presenting more than one epitope per molecule. We found that biotinylated branched structures form nanofibers that enhance recognition by the avidin protein receptor relative to similar nanostructures formed by linear peptide analogues. Biotin-avidin binding to the supramolecular nanofibers was characterized by measurement of fluorescence from nanofibers incubated with chropmophore-conjugated avidin.

引用

页码：249 / 252

页数：4

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