Renal response to L-arginine in salt-sensitive patients with essential hypertension

被引:63
作者
Higashi, Y [1 ]
Oshima, T [1 ]
Watanabe, M [1 ]
Matsuura, H [1 ]
Kajiyama, G [1 ]
机构
[1] HIROSHIMA UNIV, SCH MED,DEPT CLIN LAB MED, HIROSHIMA, JAPAN
关键词
L-arginine; nitric oxide; cyclic GMP; hypertension; sodium-dependent; blood pressure; renal circulation;
D O I
10.1161/01.HYP.27.3.643
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
This study examined whether disturbances in nitric oxide formation contribute to renal dysfunction in salt-sensitive essential hypertensive patients. We evaluated the effects of intravenous administration of L-arginine (500 mg/kg given over 30 minutes) on systemic and renal hemodynamics in 23 patients with mild essential hypertension during 1 week of a low NaCl diet (50 mmol/d) followed by 1 week of a high NaCl diet (340 mmol/d). Patients were classified as salt sensitive (n=10) or salt resistant (n=13) based on salt-induced changes in their blood pressures. Salt loading increased renal vascular resistance but not renal plasma flow in salt-sensitive patients. The L-arginine-induced renovascular relaxation was significantly reduced by a high NaCl diet (renal vascular resistance: low NaCl -12.4+/-2.3% versus high NaCl -7.1+/-1.8%, P<.001) in salt-sensitive patients, whereas it was unchanged in salt-resistant patients. The increase in plasma cGMP in response to L-arginine was also reduced by a high NaCl diet in the salt-sensitive patients (low NaCl 49+/-7% versus high NaCl 36+/-8%, P<.05) but not in the salt-resistant patients (low NaCl 51+/-6 versus high NaCl 58+/-6%). These findings suggest that NaCl loading in salt-sensitive patients with mild essential hypertension reduces the ability of L-arginine to produce nitric oxide in the endothelium of the renal vasculature.
引用
收藏
页码:643 / 648
页数:6
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