A specific anti-Helicobacter pylori agent NE2001:: Synthesis and its effect on the growth of H-pylori

被引：10

作者：

Cheng, N

Xie, JS

Zhang, MY

Shu, C

Zhu, DX ^{[1
]}

机构：

[1] Nanjing Univ, Dept Biochem, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Shanghai E Best Biopharmaceut Enterprises Co Ltd, Shanghai, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(03)00547-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis and anti-Helicobacter pylori activity of a novel agent NE2001, 4-(4-methylbenzyl)-4'-[guanidino-methylbenzoyloxy] biphenyl-4-carboxylate hydrochloride, are described. NE2001 had a specific inhibitory effect on the growth of H. pylori preceded by the suppression DNA synthesis in the cell. The effects of NE2001 on RNA and protein syntheses in H. Pylori were also examined. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2703 / 2707

页数：5

共 7 条

[1]

Helicobacter pylori uptake and efflux:: Basis for intrinsic susceptibility to antibiotics in vitro [J].