Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

被引：206

作者：

DuPage, Michel ^{[1
,2
]}

Cheung, Ann F. ^{[1
,2
]}

Mazumdar, Claire ^{[1
,2
]}

Winslow, Monte M. ^{[1
,2
]}

Bronson, Roderick ^{[3
]}

Schmidt, Leah M. ^{[1
,2
]}

Crowley, Denise ^{[1
,2
]}

Chen, Jianzhu ^{[1
,2
]}

Jacks, Tyler ^{[1
,2
,4
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Tufts Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA

[4] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

CANCER CELL | 2011年 / 19卷 / 01期

关键词：

CHRONIC VIRAL-INFECTION; ESTABLISHED TUMORS; COLORECTAL-CANCER; IMMUNE-RESPONSE; GENE-EXPRESSION; LOSS VARIANTS; SOLID TUMORS; MOUSE MODEL; IFN-GAMMA; LYMPHOCYTES;

D O I：

10.1016/j.ccr.2010.11.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond to and infiltrate tumors, significantly delaying malignant progression. Despite continued antigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. Transplantation of cell lines derived from these lung tumors or prophylactic vaccination against the autochthonous tumors, however, results in rapid tumor eradication or selection of tumors that lose antigen expression. These results provide insight into the dynamic nature of the immune response to naturally arising tumors.

引用

页码：72 / 85

页数：14

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