Subcutaneous xenotransplantation of bovine pancreatic islets

被引：31

作者：

Figliuzzi, M

Cornolti, R

Plati, T

Rajan, N

Adobati, F

Remuzzi, G

Remuzzi, A

机构：

[1] Mario Negri Inst Pharmacol Res, Dept Biomed Engn, I-24125 Bergamo, Italy

[2] Azienda Osped Osped Riuniti Bergamo, Dept Med & Transplantat, I-24125 Bergamo, Italy

[3] Mario Megri Inst, I-24125 Bergamo, Italy

来源：

BIOMATERIALS | 2005年 / 26卷 / 28期

关键词：

pancreatic islets; immunoisolation device; hollow fibers; subcutaneous site; xenotransplantation;

D O I：

10.1016/j.biomaterials.2005.02.019

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Transplantation of pancreatic islets in diabetes is currently limited by the need of immunosuppressive therapy. The present study was designed to test an immunoprotection planar device for subcutaneous xenotransplantation of pancreatic islets in the diabetic rat. We tested three different devices made of polyethersulfone hollow fibers. In all diabetic rats, implantation of islet-containing devices promptly normalized hyperglycemia. In vitro membrane permeability to glucose was correlated with implant function duration. These data confirm that bovine islets contained within devices and implanted Subcutaneously remain functional for several days. Strategies to prolong islet function may allow achieving successful long-term islet implantation in this attractive site. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5640 / 5647

页数：8

共 19 条

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