A detailed examination of cytokine abnormalities in Major Depressive Disorder

被引：235

作者：

Simon, N. M. ^{[1
,2
]}

McNamara, K. ^{[3
]}

Chow, C. W. ^{[1
,2
]}

Maser, R. S. ^{[3
]}

Papakostas, G. I. ^{[1
,2
]}

Pollack, M. H. ^{[1
,2
]}

Nierenberg, A. A. ^{[1
,2
]}

Fava, M. ^{[1
,2
]}

Wong, K. K. ^{[3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA

[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2008年 / 18卷 / 03期

关键词：

cytokines; inflammation; depression; major depressive disorder; stress; cardiovascular;

D O I：

10.1016/j.euroneuro.2007.06.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-inflammatory cytokines were significantly elevated in the MDD sample, including an antidepressant naive subset. These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：230 / 233

页数：4

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