Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)

被引：84

作者：

Almquist, Martin ^{[1
,2
]}

Johansen, Dorthe ^{[3
]}

Bjorge, Tone ^{[4
,15
]}

Ulmer, Hanno ^{[5
]}

Lindkvist, Bjorn ^{[6
]}

Stocks, Tanja ^{[7
,8
]}

Hallmans, Goran ^{[9
]}

Engeland, Anders ^{[4
,15
]}

Rapp, Kilian ^{[10
]}

Jonsson, Hakan ^{[11
]}

Selmer, Randi ^{[4
]}

Diem, Guenter ^{[12
]}

Haggstrom, Christel ^{[7
]}

Tretli, Steinar ^{[13
]}

Stattin, Par ^{[7
]}

Manjer, Jonas ^{[2
,3
,14
]}

机构：

[1] Skane Univ Hosp Lund, Dept Surg, S-22185 Lund, Sweden

[2] Lund Univ, S-22185 Lund, Sweden

[3] Skane Univ Hosp Malmo, Dept Surg, Malmo, Sweden

[4] Norwegian Inst Publ Hlth, Oslo, Norway

[5] Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria

[6] Sahlgrens Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, S-41345 Gothenburg, Sweden

[7] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden

[8] Vrije Univ Amsterdam, Inst Hlth Sci, Amsterdam, Netherlands

[9] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[10] Univ Ulm, Inst Epidemiol, Ulm, Germany

[11] Umea Univ, Dept Radiat Sci, Umea, Sweden

[12] Agcy Social & Prevent Med, Bregenz, Austria

[13] Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway

[14] Lund Univ, Malmo Diet & Canc Study, Malmo, Sweden

[15] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway

来源：

CANCER CAUSES & CONTROL | 2011年 / 22卷 / 05期

基金：

瑞典研究理事会;

关键词：

Thyroid cancer; Epidemiology; Metabolic syndrome; Cohort study; POOLED ANALYSIS; REGRESSION DILUTION; REPLACEMENT THERAPY; COHORT PROFILE; NORWEGIAN MEN; POPULATION; GLUCOSE; COMPONENTS; COMPLETENESS; METAANALYSIS;

D O I：

10.1007/s10552-011-9747-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Objective To investigate metabolic factors and their possible impact on risk of thyroid cancer. Methods A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0 years at baseline were followed for on average 12.0 years. Relative risk of incident thyroid cancer was assessed by levels of BMI, blood pressure, and blood levels of glucose, cholesterol, triglycerides, and by a combined metabolic syndrome (MetS) score. Risk estimates were investigated for quintiles, and a z score distribution of exposures was analyzed using Cox proportional hazards regression. Results During follow-up, 255 women and 133 men were diagnosed with thyroid cancer. In women, there was an inverse association between glucose and thyroid cancer risk, with adjusted RR: 95% CI was 0.61 (0.41-0.90), p trend = 0.02 in the fifth versus the first quintile, and a positive association between BMI and thyroid cancer risk with a significant trend over quintiles. There was no association between the other metabolic factors, single or combined (Met-S), and thyroid cancer. Conclusion In women, BMI was positively, while blood glucose levels were inversely, associated with thyroid cancer.

引用

页码：743 / 751

页数：9

共 44 条

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