Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function

被引:154
作者
Melchjorsen, J [1 ]
Sorensen, LN [1 ]
Paludan, SR [1 ]
机构
[1] Aarhus Univ, Dept Med Microbiol & Immunol, DK-8000 Aarhus C, Denmark
关键词
host-defense; leukocytes; signal transduction; NF-kappa B; IRF-3;
D O I
10.1189/jlb.1102577
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Recruitment and activation of leukocytes are important for elimination of microbes, including viruses, from infected areas. Chemokines constitute a group of bioactive peptides that regulate leukocyte migration and also contribute to activation of these cells. Chemokines are essential mediators of inflammation and important for control of viral infections. The profile of chemokine expression contributes to shaping the immune response during viral infection, whereas viral subversion of the chemokine system allows the virus to evade antiviral activities of the host. In this review, we discuss the role of chemokines in host-defense against virus infections, and we also look deeper into the virus-cell interactions that trigger chemokine expression as well as the cellular signaling cascades involved.
引用
收藏
页码:331 / 343
页数:13
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