Mammalian cadherins and protocadherins: about cell death, synapses and processing

被引：96

作者：

Junghans, D ^{[1
]}

Haas, IG ^{[1
]}

Kemler, R ^{[1
]}

机构：

[1] Max Planck Inst Immunol, Dept Mol Embryol, D-79108 Freiburg, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2005.08.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cadherins have been known for a long time to be key elements in many important biological processes. In particular, the role of classical cadherins in mediating adhesion has been examined in great detail. Over recent years, the accumulation of experimental tools and mice mutants has allowed more refined analysis of cadherin functions, and new aspects such as signaling and synapse dynamics have become the center of interest. In addition, the study of mice lacking the entire protocadherin-gamma cluster shed the first light on a possible novel function of members of this cadherin family in synapse formation and cell survival during development.

引用

页码：446 / 452

页数：7

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