Mass spectrometric analysis of histone posttranslational modifications

被引：32

作者：

Burlingame, AL ^{[1
]}

Zhang, X ^{[1
]}

Chalkley, RJ ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

METHODS | 2005年 / 36卷 / 04期

关键词：

mass spectrometry; electron capture dissociation; histones; posttranslational modifications; quantitation;

D O I：

10.1016/j.ymeth.2005.03.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The uses of tandem and Fourier transform mass spectrometric methodologies for assignment of the posttranslational sites. and occupancies of histones and their isoforms is described employing several illustrative examples. A comparison of information that can be obtained from intact protein sequencing and proteolytic digestion is presented. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：383 / 394

页数：12

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