Comparison of DXA hip structural analysis with volumetric QCT

被引:42
作者
Prevrhal, Sven [1 ]
Shepherd, John A. [1 ]
Faulkner, Kenneth G. [3 ]
Gaither, Ken W. [3 ]
Black, Dennis M. [2 ]
Lang, Thomas E. [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94107 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco Coordinating Ctr, San Francisco, CA 94107 USA
[3] Synarc Inc, San Francisco, CA USA
关键词
bone densitometry; femur; hip structural analysis; osteoporosis; quantitative computed tomography;
D O I
10.1016/j.jocd.2007.12.001
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Hip structural analysis (HSA) estimates geometrical and mechanical properties from hip dual-energy X-ray absorptiometry (DXA) images and is widely used in osteoporosis trials. This study compares HSA to volumetric quantitative computed tomography (QCT) measurements in the same population. A total of 121 women (mean age 58 yr, mean body mass index 27 kg/m(2)) participated. Each woman received a volumetric QCT scan and DXA scan of the left hip. QCT scans were analyzed with in-house software that directly computed geometric and mechanical parameters at the neck and trochanteric regions. DXA HSA was performed with an implementation by GE/Lunar. Pair-wise linear regression of HSA variables was conducted by method to site matched QCT variables for bone density, cross-sectional area, and cross-sectional moment of inertia (CSMI) of the femur neck. HSA correlated well with QCT (r(2) = 0.67 for neck bone mineral density [BMD] and 0.5 for CSMI) and standard DXA at the neck (r(2) = 0.82 for BMD). HSA and volumetric QCT compared favorably, which supports the validity of a projective technique such as DXA to derive geometrical properties of the proximal hip.
引用
收藏
页码:232 / 236
页数:5
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