Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

被引：89

作者：

Bertrand, Emilie ^{[3
]}

Goncalves, Cristine ^{[1
,2
]}

Billiet, Ludivine ^{[1
,2
]}

Gomez, Jean Pierre ^{[1
,2
]}

Pichon, Chantal ^{[1
,2
]}

Cheradame, Herve ^{[3
]}

Midoux, Patrick ^{[1
,2
]}

Guegan, Philippe ^{[3
]}

机构：

[1] CNRS, Ctr Biophys Mol, UPR4301, INSERM, F-45071 Orleans 2, France

[2] Univ Orleans, F-45071 Orleans 2, France

[3] Univ Evry Val dEssonne, Lab LAMBE, Equipe MPI, UMR 8587, Evry, France

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 46期

关键词：

POLYETHYLENIMINE; DERIVATIVES;

D O I：

10.1039/c1cc15716g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

引用

页码：12547 / 12549

页数：3

共 21 条

[1]

[Anonymous], ENCY POLYM SCI ENG

[2]

Behr JP, 1997, CHIMIA, V51, P34

[3] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[4] Synthesis of linear polyethylenimine derivatives for DNA transfection [J].

Brissault, B ;

Kichler, A ;

Guis, C ;

Leborgne, C ;

Danos, O ;

Cheradame, H .

BIOCONJUGATE CHEMISTRY, 2003, 14 (03) :581-587

[5] Vinyl polymers based on L-histidine residues. Part 1. The thermodynamics of poly(ampholyte)s in the free and in the cross-linked gel form [J].

Casolaro, M ;

Bottari, S ;

Cappelli, A ;

Mendichi, R ;

Ito, Y .

BIOMACROMOLECULES, 2004, 5 (04) :1325-1332

[6] Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine [J].

Dehshahri, Ali ;

Oskuee, Reza K. ;

Shier, Wayne T. ;

Hatefi, Arash ;

Ramezani, Mohammad .

BIOMATERIALS, 2009, 30 (25) :4187-4194

[7] Polyethylenimine (PEI) [J].

Demeneix, Barbara ;

Behr, Jean-Paul .

NON-VIRAL VECTORS FOR GENE THERAPY, 2ND EDITION: PART 1, 2005, 53 :217-230

[8] Polyethylenimine shows properties of interest for cystic fibrosis gene therapy [J].

Ferrari, S ;

Pettenazzo, A ;

Garbati, N ;

Zacchello, F ;

Behr, JP ;

Scarpa, M .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1447 (2-3) :219-225

[9] Partial acetylation of polyethylenimine enhances in vitro gene delivery [J].

Forrest, ML ;

Meister, GE ;

Koerber, JT ;

Pack, DW .

PHARMACEUTICAL RESEARCH, 2004, 21 (02) :365-371

[10] SYNTHESIS OF N-[1-(1-SUBSTITUTED 2-OXOPROPYL)]ACRYLAMIDES AND -METHACRYLAMIDES . ISOLATION AND SOME REACTIONS OF INTERMEDIATES OF DAKIN-WEST REACTION [J].

IWAKURA, Y ;

TODA, F ;

SUZUKI, H .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (02) :440-&

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