Biomarkers for neuroAIDS: The widening scope of metabolomics

被引：25

作者：

Pendyala, Gurudutt

Want, Elizabeth J.

Webb, William

Siuzdak, Gary

Fox, Howard S.

机构：

[1] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Ctr Mass Spectrometry, La Jolla, CA 92037 USA

来源：

JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2007年 / 2卷 / 01期

关键词：

neuroAIDS; biomarkers; metabolomics; CNS; HIV; SIV; mass spectrometry;

D O I：

10.1007/s11481-006-9041-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabolomics, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and several unique characteristics. The current applications for this field are, primarily, toxicological profiling and biomarker studies. This review of metabolomics research highlights the identification of reliable biomarkers with emphasis on neuroAIDS. Such identification of candidate markers will be advantageous for tracking the progression of human immunodeficiency virus/central nervous system (HIV/CNS) disease to gain maximal benefit from antiretroviral treatment and to provide insight into the mechanism of related neuropathogenesis.

引用

页码：72 / 80

页数：9

共 77 条

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