Total synthesis of RK-397

被引：99

作者：

Denmark, SE ^{[1
]}

Fujimori, S ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 25期

关键词：

D O I：

10.1021/ja052226d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments. Copyright © 2005 American Chemical Society.

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页码：8971 / 8973

页数：3

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