The susceptibility of non-fermentative gram-negative bacilli to cefperazone and sulbactam compared with other antibacterial agents

被引:15
作者
Fu, W [1 ]
Zhu, DM [1 ]
Wu, S [1 ]
Hu, FP [1 ]
Zhang, YY [1 ]
机构
[1] Fudan Univ, Huan Shan Hosp, Inst Antibiot, Shanghai 200040, Peoples R China
关键词
cefoperazone/sulbactam; non-fermentative gram-negative bacilli; bacterial susceptibility testing;
D O I
10.1016/S0924-8579(03)00109-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
This study was designed to determine the bacterial susceptibility of non-fermentative Gram-negative organisms to various antibacterial agents. Bacterial susceptibility testing used the Kirby-Bauer method and data were assessed according to NCCLS 2000. Cefoperazone/sulbactam (CPER/SU) had good antibacterial activity against Pseudomonas aeruginosa. Its activity was next only to that of imipenem, meropenem and ceftazidime. CPER/SU was highly active against Acinetobacter spp., Alcaligenes spp., Burkholdria spp., Stenotrophomonas maltophilia and Flavobacterium spp., while the majority of strains of the latter two species were resistant to imipenem and meropenem. Of 3905 isolates tested, 39.5% were susceptible to CPER, 70.4% to CPER/SU. The resistance rate was 37% for CPER and 10.8% for CPER/SU. (C) 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:444 / 448
页数:5
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