Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail

被引：238

作者：

Sambhy, Varun ^{[1
]}

Peterson, Blake R. ^{[1
]}

Sen, Ayusman ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期

关键词：

antibiotics; hydrophobic interactions; polymerization; polymers; structure-activity relationships;

D O I：

10.1002/anie.200702287

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) The benefits of separation: For homologous polymers having similar backbone composition and charge/tail ratios, placing the charge and alkyl tail on spatially separated centers results in a higher membrane-disrupting ability, as evident from the increased antibacterial and hemolyticac tivities. The spatial separation particularly amplifies mammalian cell toxicity (see picture). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1250 / 1254

页数：5

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